CLSI NBS06 A : 1ED 2013

Abstract
Committee Membership
Foreword
1 Scope
2 Introduction
3 Standard Precautions
4 Terminology
5 Biology of Severe Combined Immunodeficiency
6 Biological and Clinical Features of Severe
  Combined Immunodeficiency
7 Overview of Quantitative Polymerase Chain
  Reaction Assays
8 Implementation of T-cell Receptor Excision
  Circle Assay
9 Follow-up Activities, Communication, and
  Diagnostic Testing
References
Appendix A - Immunodeficiency Disorders and T-cell
             Receptor Excision Circle Values in the
             Newborn Screening Period
Appendix B - Generic Flow Chart for Assays to Measure T-cell
             Receptor Excision Circles in newborn Dried
             Blood Spot Specimens
Appendix C - Example Algorithms Used for Severe Combined
             Immunodeficiency Newborn Screening Testing
             and Follow-up
Appendix D - References Materials for the T-cell Receptor
             Excision Circle Assay in Dried Blood Spot
             Specimens
Appendix E - Example of a Daily Work Plan for Severe
             Combined Immunodeficiency Newborn Screening
The Quality Management System Approach
Related CLSI Reference Materials

Specifies the detection of severe combined immunodeficiency (SCID) by population-based newborn screening using dried blood spot specimens to measure T-cell receptor excision circles.